Alright, I'm about to throw Quark somewhere.
It was working absolutely fine up until about an hour ago. Suddenly the icons in the left toolbar are gone, as are *most* of the icons in the right side panels (Page layout, colors, layers, etc.)
Here's a screen grab to show you what I mean: http://www.ubermick.com/images/quarkscreen.png
I've trashed the preference files, restarted, rebuilt preferences, zapped PRAM, all to no avail. I'd blame the Lion update form 10.7.2 to 10.7.3 yesterday, but as I mentioned, I was using it this morning and didn't see an issue.
Thoughts?